Wednesday, May 22, 2013

COMPANIES GETTING UNFAIRLY SLIMED BY BAD SCIENCE




Here is something that drives me nuts:  watching the media and courts trash companies for selling a “dangerous” product when there is no scientific evidence to back up their allegations.  I suppose the most egregious example is the decimation of Dow Corning due to the silicone breast implant debacle that began in the mid 1980’s and lasted through the 1990’s.  Now we have the “pink slime” fiasco, which is ongoing.

You may recall that in 1984 Dow Corning lost a suit on the basis that silicone breast implants caused immunological problems for the recipient.  The initial $1.7 million award of damages was just the beginning—lawsuits poured in and money poured out.  In December of 1990, the “Face to Face” TV show hosted by Connie Chung aired a special on “the dangers of silicone breast implants.”  In 1991 Ralph Nader’s Public Citizen Health Research Group sent out warnings that silicone breast implants caused cancer.   By December 1991, 137 individual lawsuits had been filed against Dow Corning.  By December 1993, the number was 12,359 .  By December 1994, it was 19,092.

So in May 1995, a beleaguered Dow Corning filed for bankruptcy protection, and in November 1998 it applied for bankruptcy reorganization, which included $3.2 billion in previously agreed-to settlements.  The bankruptcy was settled in 1999, but it took several more years for the litigation over the settlement to wind down.  Dow finally managed to extricate itself from the bankruptcy courts in 2004.

What makes this story so outrageous is that the scientific community knew by 1991 that there was no scientific basis for the claims.  And throughout the remainder of the 1990’s, report after report showed no relationship between silicone implants and systemic disease. Too bad for Dow, though.  The damage to the company had already been done. “Sorry guys!  We just wrecked your company.  Oops!  Oh, and by the way, you don’t get your money back.”

But amazingly, Dow Corning survived, and it continues today as a multinational corporation that provides over 7,000 products and services, most of which are based on silicon:  semi-conductors, solar panels, cookware, sound absorbents, etc., etc.

But it seems that Dow Corning will never be put out of its misery completely insofar as breast implants are concerned: a court in Korea just ruled against Dow in a class action suit that is apparently based on implants that have burst.  Of course, these claims are different in that they don’t seem to involve allegations that the implants cause disease.  I  don’t know what the company’s position is regarding the stability of the implants they sell, but this seems like an aesthetic issue rather than a health issue to me.

And I just have to hit one of my own hot-buttons: science illiteracy in a nation absolutely dependent on high technology and related industries.   Scary.   But since I’ve already talked about pseudo-science in my blog about the alleged link between vaccines and autism, I’ll leave it there.

But there is a more recent public “scandal” that has resulted in another company’s near-bankruptcy:   pink slime. 

Here is the deal:   meat processors routinely remove fatty areas from beef carcasses, and these trimmings often include some residual meat.   Basically, you can do three things with these trimmings:  throw them out, feed them to animals, or feed them to humans.  The slaughter business, like all industries associated with feed and food production, has become incredibly competitive—with very low profit margins.  And when you are slaughtering thousands of animals, an improvement to the process can make the difference between having a profitable or an unprofitable day, even if that improvement only amounts to an increased profit of pennies per carcass.

Now, I don’t know how many of you have actually butchered an animal—maybe you think meat comes from the supermarket, where it was spontaneously produced on the spot.  But, having done it myself many many times, and having visited slaughterhouses, I can tell you that it is a gross, messy, nasty, unappetizing, and rather sad business.   I mean, no normal person could possibly believe that seeing beautiful animals converted into hunks of meat is a pretty sight.

And no matter who does the butchering, the process is rife with possibilities for contamination.  In particular, E. coli contamination from excrement.  That’s right—if you’ve ever seen a cow, then you know it is smeared with feces.  And when you butcher that animal, it is inevitable that some of the E. coli in the feces will come in contact with the resulting meat.  Think about it—when a knife goes in to start a slit in the hide, bacteria may be dragged in along with the blade.  It is just unavoidable.  And there are some strains of E. coli that are particularly nasty and potentially lethal to humans—the bad actor being the famous strain called 0157:H7.  Most of the news articles reporting contaminated beef products, as well as vegetables and fruits, involve this one bug.

So the world has expended a lot of resources in trying to kill E. coli 0157:H7.   The process we are concerned with, which has been around since 1990, consists of taking meat trimmings, warming them up to between 107F to 109F, and spinning them in a centrifuge, which separates the fat from the meat.  This meat is flash frozen at 15F for 90 seconds and then exposed to extreme pressure that forms it into blocks or tubes.  Apparently the combination of low temperature and high pressure ruptures cell walls, thus killing the bacteria.

By the mid 1990’s, the public was becoming increasingly concerned about E. coli, and so American inventor Eldon Roth, founder of a company called Beef Products Incorporated (BPI), started experimenting.  To date he has at least 68 patents that cover various ways of sterilizing meat.  The patents that are critical to this story seem to have issued in 2002, claiming a sterilization method that involves the injection of gaseous ammonia (NH3) into meat.   Upon contact with water in the meat, NH3 forms ammonium hydroxide, a very “basic” compound (the opposite of acidic) that kills the bacteria.   The USDA’s Food Safety and Inspection Service approved this disinfection procedure in 2001.

The final product is apparently 94% to 97% meat.  Its formal name is “lean finely textured beef,” or LFTB.  I should also point out that LFTB is also produced with citric acid as a replacement for ammonia gas (sold by Cargill).  Tyson Foods also sells LFTB, apparently buying it from other producers. 

In early March 2012, LFTB was found in 70% of the ground beef sold in the U.S.   According to USDA restrictions, ground beef that is more than 15% LFTB must be labeled as containing LFTB, but if it contains less than 15%, you can’t tell just by looking at the package that there is any at all.   LFTB cannot be sold directly to consumers—it is mixed in with ground beef at, for example, grocery stores.

In 2007 there was such high confidence in LFTB disinfected with ammonia gas that the USDA exempted it from routine testing.

So, up until December 30, 2009, the public knew nothing about LFTB and had happily consumed millions of pounds of the stuff.  Then the New York Times published an article* that disparaged Eldon Roth (he wasn’t a “scientist”) and questioned the safety of the product.  It  reported that some of the LFTB produced by Beef Products Inc. had higher levels of bacterial contamination than the USDA allowed and mentioned that people had objected to the smell of ammonia in LFTB, apparently before it was mixed with ground beef.  The article also stated that two 27,000-pound batches of LFTB had been recalled:  “The meat was caught before reaching lunch-rooms [sic] trays.” Snatched from the mouths of babes!

Oops.  Then on January 12, 2010, the New York Times published a correction stating that the two “recalled” batches mentioned above had actually been discovered by Beef Products Inc. before being shipped.   The NY Times also admitted that “[n]o meat produced by Beef Products Inc. has been linked to any illnesses or outbreaks.”  I bet the editors were sorry about having to make that confession.  No story there.

The 2009 article also mentioned that LFTB was also known as “pink slime,” a name apparently coined in 2002 by an employee within the USDA.  Although “pink slime” was used as a pejorative, it really didn’t catch on with the public until March 2012, when ABC News used the term to hype a series of stories about LFTB.

What exactly the public’s concern was/is with LFTB, I can’t really fathom.  LFTB is 97% beef—so what’s the beef?  It’s ALL beef!  Was it because people actually had to think about what can go into hamburger (“trimmings”)?  Did they really believe that hamburger was just ground-up sirloin?  Was it concern about the safety of the ammonia gas used to sterilize the final product?  (There was some ridiculous media coverage involving a cook pouring a bottle of ammonia cleaner onto “trimmings” and then putting the whole mess into a washing machine to make “pink slime.”  As if ammonia is something unusual—it is a natural product in our bodies, a part of every protein molecule.)  Was it because the labels on their meat failed to state that two different forms of hamburger had been mixed together?  Was it because of LFTB’s industrial production?  (What’s wrong with that—how do they think it ought to be produced?)

Although the media tried very hard to make the case that LFTB was “contaminated,” that never really stuck, except in the minds of some particularly squeamish consumers.  The ammonia process works.  It is clean.  It is harmless to humans.  It remains USDA approved to this day.

In addition, ammonium hydroxide is used as a direct food ingredient in almost every processed food you buy in the grocery store—baked goods, cheeses, chocolates, and pastries.  Ammonia in other formulations—ammonium sulfate, ammonium alginate—is used in condiments, relishes, soy protein, snack foods, jams, jellies, and beverages.  There are hundreds of food products listed by the World Health Organization that use ammonium hydroxide, including dairy products, fruits, vegetables, cereals, eggs, fish, and BEER (and how many times have you seen a beer-drinker take a good long swig and say, “Gross, this smells like ammonia”?)

In any event, all of the negative publicity resulted in BPI closing down three of its four plants.  Safeway, SUPERVALU, and Food Lion stopped selling LFTB hamburger.  McDonald’s, Burger King, and Taco Bell announced they would discontinue using BPI’s LFTB in their products.  Wendy’s reported they never used LFTB in the first place.  Five Guys stated that they don’t use “ammoniated procedures.”  (I guess they don’t sell products made by animals, since all animals use “ammoniated procedures.”) Further, various school systems announced they would stop serving LFTB hamburger.  I guess outlawing beef is next.

And so it went through 2012, one absurd news report after another, and a public apparently unable to comprehend where their food comes from.

Anyway, BPI may just have the last word.  On September 13, 2012, BPI filed a $1.2 billion lawsuit against ABC News and three reporters—Diane Sawyer, Jim Avila, and David Kerley.  BPI claimed damages as a result of ABC’s reports on “pink slime.”  This will be an interesting case to watch.

In looking at the Dow Corning case as well as the BPI case, it seems to me what they have in common is a sometimes-ignorant press featuring sensationalized stories, an impressionable public, and a generalized antipathy towards industry.

This combination, which is so lethal to industry, may slowly be rectified by the development of laws that offer some protection from scientific fraud. 

A good place to begin is with “expert” witnesses.  Clearly Dow suffered from expert witnesses testifying that in their “expert” opinion, silicon implants caused health problems.  The problem is that not all experts are expert.

In recognition of this problem, the Supreme Court  developed guidelines, called the “Daubert standard,” for the admissibility of expert witness testimony in federal courts.  This allows judges to keep out evidence that they deem unqualified.  The Daubert standard was articulated by the Supreme Court as a result of three cases heard by the Court the 1990’s, and by the year 2000, it was codified in the Federal Rules of Evidence.  After some tinkering with the wording, Rule 702 (Testimony of Experts) now reads as follows

A witness who is qualified as an expert by knowledge, skill, experience, training, or education may testify in the form of an opinion or otherwise if:
(a)         The expert’s scientific, technical, or other specialized knowledge will help the trier of fact to understand the evidence or to determine a fact in issue;
(b)         The testimony is based on sufficient facts or data;
(c)         The testimony is the product of reliable principles and methods; and
(d)         The expert has reliably applied the principles and methods to the facts of the case.

Isn’t it amazing that it took until the year 2000 for these rules to be adopted?  I mean, they just represent good scientific procedure.  But even at that, the Daubert standard is followed only in the federal courts and in something over half of the state courts.  Florida has passed a bill adopting the Daubert standard that is awaiting signature by the Governor.  Canada has used the Daubert standard in at least two cases, and in the United Kingdom a recommendation has been made to formulate a test that “builds” on the Daubert standard. 

In all fairness, the courts were not entirely without guidance with regard to the admissibility of expert testimony prior to Daubert.  The standard previously in use was called the Frye test, and the critical difference between the two was that Frye permitted only testimony that was “generally accepted by experts.”  That was okay, but it did not allow for new scientific findings that had not yet been widely accepted.  So Daubert substitutes a “reliability” test based on scientific principles and methods for the Frye “general acceptance” test.  This means that, under Daubert, if expert testimony is deemed reliable, the judge can allow it to come in, even if it is so new that it is not yet generally accepted by the majority of experts in the field.

The Daubert standard is often criticized for requiring that judges be scientifically literate.  I don’t know why this is a problem—I expect that judges SHOULD be more scientifically literate than jury members.  They are judges, after all.  Another criticism is that Daubert may set an evidentiary standard that is too high for many plaintiffs to reach—well, duh, that is the general idea, to get rid of spurious “evidence.”  As an indication that the new standard is working, a 2002 RAND study found that the percentage of proposed scientific testimony that was excluded by the courts actually ROSE after Daubert.  I presume that is because junk science got rejected.  That can’t be a bad thing.

I don’t know whether the Daubert standard will get used in BPI’s suit against ABC, as that case seems to primarily revolve around the issue of libel.  That is, I don’t know whether experts will testify in that case as to the safety of ammoniated LFTB since that does not seem to be the primary issue.  But ABC may call experts to prove that what it said about LFTB was true, and BPI may call experts to prove that it wasn’t.  And in that case, the Daubert standard will apply.

In any event, if the Daubert standard had been part of the Federal Rules of Evidence a little earlier, Dow Corning might still be happily making silicone breast implants since much of the so-called “expert” testimony introduced by the plaintiffs in those cases would almost certainly have been thrown out. 


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